Binding affinity

In physiology, binding affinity refers to the chemical force of affinity involved in the attraction or attachment of one chemical entity to another, of two molecules to each other, or of one molecule to a surface, such as a drug to a receptor (or host to a guest). Binding affinity is typically quantified via free energy or of enthalpic and entropic terms.

Further reading
● Lybrand, Terry P, McCammon, J. Andrew, and Wipff, George. (1986). “Theoretical Calculation of Relative Binding Affinity in Host-Guest Systems.” Proc. Natl. Acad. Sci. USA, Vol. 83. Pp. 833-35.
● Talhout, Reinskje. (2003). Understanding Enzyme Binding Affinity: Thermodynamics of Binding of Benzamidinium Chloride Inhibitors to Trypsin, Dissertation. Rijksuniversiteit Groningen.
● Gomperts, B. D., Kramer, Ijsbrand M, and Tatham, Peter E.R. (2009). Signal Transduction (section: Measurement of binding affinity, pg. 30). Academic Press.
● Michel, Julien and Essex, Johathan W. (2010). “Prediction of Protein-Ligand Binding Affinity by Free Energy Simulations: Assumptions, Pitfalls, and Expectations” (abstract), Journal of Computer-Aided Molecular Design, May 28.

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