|American chemical engineer William Fairburn's 1914 Human Chemistry, is the first book to treat humans explicitly as "chemicals" according to which the job of the manager or organizer of people as the executive "human chemist", who works to prevent explosions, facilitate working interactions, via measurements of human energies and entropies.|
In his book, Fariburn declares that “today there are eighty-one known elements” and openly discusses his views that people, as combinations of these elements, are “human chemical elements” and that the job of the “human chemist”, i.e. the manager or foreman, is to achieve successful “reactions resulting from combinations of individuals”. Fairburn states that human reactions can be quantified by energy and entropy changes and on the topic of affinity chemistry, he states:
“Just as there are many affinities among the chemical elements, so there are many possible harmonious combinations of human workers; some of these harmonious combinations, however, of both chemical and human elements, may become violently explosive when subjected to an outside influence.”
Fairburn’s general view, however, is rather elementary, being half metaphorical and half suppositional in theme, and he uses no formulas. In commentary on the relationship of entropy, S, to human reactions (relationships), for instance, he states:
“The classified division of entropy, referring to temperature changes which can be likened to coolness, passion, explosiveness and frigidity, are all interesting but of themselves prove little.”
In the modern sense, the nature of entropy in human chemical reactions is a in depth topic. In a reaction in which a group of human molecules (people) are thrown into a closed reaction vessel, such as the grounds of the estate in Goethe's novella or a isolated island, the following affinity formula will dictate the progression of the overall process:
When more factors are added in, such as movements of chemical species into or out of the system or external influences (forces), the nature of the study and prediction of human chemical reactions becomes immensely more complicated. 
1. Fairburn, William Armstrong. (1914). Human Chemistry. The Nation Valley Press.
2. (a) Thims, Libb. (2007). Human Chemistry (Volume One). Morrisville, NC: LuLu.
(b) Thims, Libb. (2007). Human Chemistry (Volume Two). Morrisville, NC: LuLu.