|Generic diagram of the typical male-female reaction, depicted using Bergman-style letter notation of single letters, A or B, used to represent unattached molecular entities and adjacent letters, AB, to represent bonded chemical entities. |
In 2001, American computation chemist David Hwang, in his “The Thermodynamics of Love”, defined a male-female reaction as a theoretical chemical reaction where two elements, "male" (M) and "female" (F), combine to form a new compound called "couple" (M-F): 
M + F → M-F
Hwang goes on to explain the chemical thermodynamics of this reaction in his mating free energy principle.
1. (a) Thims, Libb. (2007). Human Chemistry (Volume One). Morrisville, NC: LuLu.
(b) Thims, Libb. (2007). Human Chemistry (Volume Two). Morrisville, NC: LuLu.
2. Hwang, David. (2001). "The Thermodynamics of Love" (PDF), Journal of Hybrid Vigor, Issue 1, Emory University.
3. Bergman, Torbern. (1775). A Dissertation on Elective Attractions. London: Frank Cass & Co.