|A meaninglessness screensaver, representative of “insignificance”, to a Reddit atheism thread (Ѻ) on “significance” in the big universe.|
The following are related quotes:
“The only absolute knowledge attained by man is that life is meaningless.”— Leo Tolstoy (c.1890) (Ѻ)
“I believe that I am not responsible for the meaningfulness or meaninglessness of life, but that I am responsible for what I do with the life I’ve got.”— Hermann Hesse (c.1920) (Ѻ)
“I had motive for not wanting the world to have a meaning; consequently assumed that it had none, and was able without any difficulty to find satisfying reasons for this assumption. The philosopher who finds no meaning in the world is not concerned exclusively with a problem in pure metaphysics, he is also concerned to prove that there is no valid reason why he personally should not do as he wants to do, or why his friends should not seize political power and govern in the way that they find most advantageous to themselves. … For myself, the philosophy of meaninglessness was essentially an instrument of liberation, sexual and political.”— Aldous Huxley (1937), Ends and Means: an Inquiry into the Nature of Ideals 
“The modern Shelleyan monster is one who is nobody’s child but the scientists own and whose taming is no practical task. I mean an invisible demon who works by subtle poison, not upon the flesh and bone, but upon the spirit. I refer to the monster of meaningless. The psychic malaise. The existential void where modern man searches for his soul.”—Theodore Roszak (c.1975) "Article"; cited by Leon Cooper (1977) in Science and Human Experience 
“Some have described today’s young people as ‘the first generation to live after the death of god.’ Here we are searching from something beautiful, yet the whole source of beauty has been robbed from us. The amazing and romantic world around us is explained away as a freak of nature—our dearest friends are really only heaps of meaningless matter that evolved from a puddle of sludge. And love itself is but a chemical reaction inside our brains that takes place when our impulse to propagate the species kicks into gear. To be honest, if modern science is right and all that exists is nothing but the result of a great big bang, then I would be the first to say that you are crazy if you wait to indulge your desires. I mean, if you and the ‘love of your life’ are only heaps of meaningless matter, then hurry up and ignite the chemical reaction!”— Eric Ludy (1999), When God Writes Your Love Story: the Ultimate Guide to Guy/Girl Relationships 
“Bertrand Russell's view —that ‘man is the product of causes which had no prevision of the end they were achieving; that his origin, his growth, his hopes and fears, his loves and beliefs, are but the outcome of accidental collections of atoms’—expresses the terrible poetry of a meaningless universe, rolling along entropic channels of chance, blind and without purpose, sometime accidentally throwing up the magnificence and beauty of natural and human creations.”— Christian de Quincey (2002), Radical Nature 
|A "meaningless" screensaver or wallpaper.|
● Purposeless universe hypothesis
1. Meaning – EtymOnline.com.
2. Huxley, Aldous. (1937). Ends and Means: an Inquiry into the Nature of Ideals (meaninglessness, 4+ pgs; quote, pg. 270). Harper Collins.
3. (a) Ludy, Eric and Ludy, Leslie. (1999). When God Writes Your Love Story: the Ultimate Guide to Guy/Girl Relationships (pg. 136). Random House.
(b) When God Writes Your Life Story – Wikipedia.
4. (a) Russell, Bertrand. (1923). “A Free Man’s Worship”, T.B. Mosher.
(b) Russell, Bertrand. (1961). “A Free Man’s Worship”, in: R.E. Egner and L.D. Dennon, eds., The Basic Writings of Bertrand Russell 1903-1959. Simon and Schuster.
(c) De Quincey, Christian. (2002). Radical Nature: Rediscovering the Soul of Matter (pgs. 13, 23). Invisible Cities Press.
5. (a) Roszack, Theodore. (c.1975). “Article” (Ѻ), Daedalus.
(b) Cooper, Leon N. (1976). Science and the Human Experience: Mephistopheles is Alive and Well and Living in the Space Age – Values, Culture, and Mind (Amz) (pg. 43). Cambridge University Press.