Peter Mitchell

Peter Mitchell nsIn science, Peter Mitchell (1920-1992) was an English biochemist noted for his

In 1961, Mitchell introduced his chemiosmotic theory of membrane energy transduction, in which he showed that ATP synthesis, in the mitochondria, was coupled to electrochemical gradients. [1]

In 1977, in commenting in retrospect Mitchell stated: [3]

“In 1961, the four postulates were almost entirely hypothetical; now after sixteen years of experimental scrutiny, they are now generally accepted as experimental facts. My 1966 review has been frequently cited because it was the first paper in which the chemiosmotic rational was discussed in depth, and examined stoichiometrically, thermodynamically, kinetically, and mechanistically in light of available experimental data on the systems described by the four postulates.”

His 1966 review of his theory, entitled “Chemiosmotic Coupling in Oxidative and Photosynthetic Phosphorylation”, went on to become a citation. [2] Mitchell is loosely considered the founder of membrane bioenergetics. [4] Mitchell received the 1978 Nobel Prize for his theory and in his Nobel Lecture cites what he calls the “rather abstract thermodynamic treatment” of chemical transport described in Edward Guggenheim’s 1933 thermodynamics textbook. [5]

Mitchell completed undergraduate work at Queen’s College in the 1940s. In 1942, he began research in the biochemistry department of Cambridge completing his PhD there in 1950 on the topic of the mode of action of penicillin. In 1955, he became the head of the biochemical research unit at Edinburg University, staying there until 1963.

1. Peter Mitchell (1961). "Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism". Nature 191: 144–148.
2. Mitchell, Peter. (1966). “Chemiosmotic Coupling in Oxidative and Photosynthetic Phosphorylation” (abstract), Bio. Rev. Cambridge Phil. Soc. 41: 445-502.
3. Mitchell, Peter. (1978). “Chemiosmotic Coupling: 1966”, Citation Classics, 16: 193. Apr 17.
4. Nicholls, David G. and Ferguson, Stuart J. (2001). Bioenergetics3 (pg. ix) New York: Academic Press.
5. Mitchell, Peter. (1978). “David Keilin’s Respiratory Chain Concept and its Chemiosmotic Consequences”, Nobel Lecture, pgs. 1-36. Dec 08.

External links
Peter D. Mitchell – Wikipedia.
Peter Mitchell –
Peter Dennis Mitchell –

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