|American mathematician Stephen Smale (Ѻ) at the Institute for Science and Technology, Australia, lecturing on Anfinsen’s dogma, aka the thermodynamic hypothesis.|
The hypothesis was put forward by American biochemist Christian Anfinsen in the 1950s who reasoned that the information determining the tertiary structure of a protein resides in the chemistry of its amino acid sequence. Investigations on reversible denaturation of several proteins served to verify this proposal experimentally. The paper presenting his theory seems to be the 1973 article “Principles that Govern the Folding of Protein Chains”, in which he showed that under the proper solvent conditions, amino acid sequence fold spontaneously into functional three-dimensional protein structures, and that the process was governed thermodynamically.  Anfinsen won half the 1972 Nobel Prize in chemistry for this work on “ribonuclease, especially concerning the connection between the amino acid sequence and the biologically active conformation.” 
1. Anfinsen, C.B. (1973). “Principles that Govern the Folding of Protein Chains” (abstract) Science, 181: 223-30.
2. Larson, Scott A. and Hilser, Vincent J. (2004). “Analysis of the ‘Thermodynamic Information Content’ of a Homo sapiens Structural Database reveals Hierarchical Thermodynamic Organization”, Protein Science, 13: 1787-1801.
3. Anfinsen, Christian B. (1972). “Studies on the Principles that Govern the Folding of Protein Chains.” Nobel Lecture, Dec. 11.
● Anfinsen’s dogma – Wikipedia.